Presentation Title: “Simultaneous XRD-DSC: Powerful Technique to Determine Glass Stability of Sulfonyl Urea Analogues in the Presence of a Crystallization Inhibitor”
Abstract: Drug−polymer dispersions are known to physically stabilize amorphous drugs against recrystallization. Identification of crystallization induction time under several isothermal conditions allows the construction of time−temperature-transformation (TTT) plots, which capture the glass stability of an amorphous system. However, measurement of drug recrystallization onsets in the presence of polymer is analytically complex, owing to difficulties in detecting early recrystallization of the drug in a largely amorphous background. Simultaneous X-ray diffraction–differential scanning calorimetry (XRD-DSC) measurements on these samples can increase confidence in the detection of recrystallization onset while also characterizing polymorphs that may grow at different temperatures.
Biography: Mustafa Bookwala is a Ph.D. candidate in the Graduate School of Pharmaceutical Sciences at Duquesne University, doing research under the guidance of Dr. Peter L. D. Wildfong. His dissertation project aims to understand the implications of drug-polymer coexistent halogen and hydrogen bonds on the physical stability of amorphous solid dispersions. Mustafa was awarded the prestigious 2022 NIPTE-Rigaku research scholarship to pursue fundamental scientific research at the advanced laboratory at Rigaku. He is the chair of the Duquesne University American Association of Pharmaceutical Scientists (AAPS) Student chapter. Also, Mustafa serves on the AAPS Student Program Support Committee to bring the outlook and experience of a graduate student and an early-stage researcher. Mustafa enjoys learning about material science and pharmaceutical formulations and is passionate about improving human lives by contributing to science.